Spyre Therapeutics, Inc. (SYRE) Stock

Healthcare · Biotechnology · Member of Other US Stocks

Spyre Therapeutics, Inc. (SYRE) closed at USD 80.10 on 2026-10-15, a change of +236.1 % over the past year, with a market capitalization of USD 7.47B.

Spyre Therapeutics, Inc. recent closing prices

DateClose (USD)
2026-10-1580.10
2026-10-1478.63
2026-10-1380.45
2026-10-1285.90
2026-10-0985.69
2026-10-0879.90
2026-10-0780.85

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Spyre Therapeutics, Inc. key figures

Previous close
USD 80.10 (2026-10-15)
1-year change
+236.1 %
Market cap
USD 7.47B
Enterprise value
USD 6.05B
P/E ratio (trailing)
-41.62
P/E ratio (forward)
-22.68
EPS (trailing)
-1.92
EPS (forward)
-3.52
PEG ratio
n/a
Price to book
7.37
Revenue growth
n/a
Earnings growth
n/a
Dividend per share (trailing)
0.00
Short ratio
9.85
Employees
125
Analyst consensus (third-party)
strong_buy

Source: Yahoo Finance via yfinance. Data may be delayed, incomplete or incorrect.

About Spyre Therapeutics, Inc.

Spyre Therapeutics, Inc., a clinical stage biotechnology company, focuses on developing therapeutics for patients living with inflammatory bowel disease (IBD) and rheumatic diseases. The company develops SPY001, a humanized monoclonal immunoglobulin G1 antibody that is in phase-2 clinical stage designed to bind selectively to the a4ß7 integrin being developed for the treatment of IBD (ulcerative colitis and Crohn's disease); and SPY002 and SPY072 – anti-TL1A mAbs designed to bind to tumor necrosis factor-like ligand 1A (TL1A). It is also developing SPY003, a clinical-stage program, which is in phase-2 clinical stage designed to bind to interleukin 23 (IL-23); SPY120, a combination of anti-a4ß7 and anti-TL1A mAbs; SPY130, a combination anti-a4ß7 and anti-IL-23 mAbs; and SPY230, a combination anti-TL1A and anti-IL-23 mAbs. The company was formerly known as Aeglea BioTherapeutics, Inc. and changed its name to Spyre Therapeutics, Inc. in November 2023. The company was incorporated in 2013 and is based in Waltham, Massachusetts.

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